The pathological changes were diffuse pulmonary interstitial inflammation and alveolar damages with apoptosis and desquamation of pneumocytes in alveolar spaces, hyaline-membrane formation, wider alveolar walls and predominant lymphocyte and mononuclear inflammatory infiltrates. 结果:肺部病变主要表现为弥散性肺间质炎症及肺泡损伤,肺泡上皮细胞凋亡脱落及肺透明膜形成,肺间隔明显增宽,以淋巴细胞和单核细胞为主的炎细胞浸润。
Acute lung injury ( ALI) is a disease process characterized by diffuse inflammation in the lung parenchyma. ALI是一个以肺实质弥散性炎症为特征的疾病过程,炎症调节物在ALI发病中的作用一直是研究的热点。
Research background: Pulmonary fibrosis is to diffuse alveolar units of chronic inflammation and fibrosis is the main pathological features are a class of diseases, including idiopathic pulmonary interstitial fibrosis and secondary to pulmonary interstitial fibrosis. 研究背景:肺纤维化是以弥漫性肺泡单位慢性炎症和间质纤维化为主要病理特征的一类疾病,主要包括特发性肺间质纤维化及继发性肺间质纤维化。